Prolonged remission in chronic myeloid leukemia after one course of busulfan.

نویسندگان

  • M Djaldetti
  • B Padeh
  • J Pinkhas
  • A De Vries
چکیده

P ROLONGED REMISSIONS in chronic myeloid leukemia following treatment with busulfan have been reported by various authors.’-” Although lengthy periods of latency of the disease following cytostatic treatment are not uncommon, the observation of a complete clinical and hematologic remission of nearly 7 years duration in a patient with chronic myeloid leukemia following a single course of busulfan seems sufficiently rare to justify its description.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Dibromomannitol in the treatment of chronic granulocytic leukemia: a prospective randomized comparison with busulfan.

Dibromomannitol (DBM) is a new agent for the treatment of chronic granulocytic leukemia. A propsective evaluation of the drug was undertaken in a randomized comparison with busulfan. Forty previously untreated, Philadelphia chromosome-positive cases were treated, with 20 patients in each treatment group. The protocol provided for continuous maintenance therapy after remission induction, with a ...

متن کامل

A randomized trial comparing interferon-alpha with busulfan for newly diagnosed chronic myelogenous leukemia in chronic phase.

A multicenter randomized study was conducted to compare the effect of interferon-alpha (IFN-alpha) with that of busulfan in newly diagnosed patients with chronic myelogenous leukemia (CML) in chronic phase. From October 1988 to October 1991, 170 patients were randomized to receive either IFN-alpha or busulfan. Of 159 eligible patients, 31 (38.8%) of 80 patients in the IFN-alpha group and 43 (54...

متن کامل

Chronic myeloid leukemia: changing the treatment paradigms.

Molecular discoveries and clinical advances over the past few decades have made the treatment of chronic myeloid leukemia (CML) one of the great success stories of modern medicine. Before the 1980s, the focus was on maintaining normal white blood cell counts with agents such as hydroxyurea and busulfan. With the use of interferon, treatment strategies turned more toward cytogenetic remission. I...

متن کامل

Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia.

PURPOSE Intensification by high-dose cytarabine in postremission or induction therapy and prolonged maintenance are established strategies to improve the outcome in patients with acute myeloid leukemia (AML). Whether additional intensification can add to this effect has not yet been determined. PATIENTS AND METHODS A total of 1,770 patients (age 16 to 85 years) with de novo or secondary AML o...

متن کامل

لوسمی میلوئید مزمن در کودکان و گزارش یک مورد

SUMMARY Chronic Myeloid Leukemia In Children And a Case – Report Dr. Roya Ejte mai , Assistant. professor, Gilan University of medical Sciences, Rasht . The case is a ten-years - old boy. During examinations for massive splenomegaly, his disease has been diagnosed chronic Myelogenous leukemia (CML), and also philadelphia chromosome was revealed during chromosomal analysis. The patient was t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Blood

دوره 27 1  شماره 

صفحات  -

تاریخ انتشار 1966